14 Jul 2019

How About A Holiday?

June 24, 2019

By Dr. Dorothy Colagiovanni

The concept of a drug holiday is standard medical practice for chronic users of pharmaceutical medications.  Physicians use this abstinence tactic for a variety of reasons, including: limiting side effects of a medicine or allowing a patient to maintain sensitivity to a drug’s effect.  When using cannabis, we often talk about tolerance: the need for greater and greater amounts to achieve the same desired effect, be it for pain relief or simply to get high.  I would like to recommend the drug holiday concept for chronic cannabis users as a way to modulate the endocannabinoid system (ECS) and save the consumer some hard-earned cash.


The central piece of the ECS that is important to cannabis consumption is THC binding to the CB1 receptor.  As previously discussed in CBE, this binding is what leads to the psychoactivity (or, the high) of cannabis consumption.  With chronic cannabis use, the receptors are downregulated, or reduced in number, at the cell surface at sites of action.  This reduced response means that over time it requires more THC to bind to the receptors for an equal effect, all the while spending more and more money.


So, how can cannabis users save money and still get the same high?  Start taking a weekly cannabis break (or holiday, as they say in England)!


Read the full article here: How About A Holiday?

14 Jul 2019

Taking the Pulse of the Industry Today: Two Prominent Researchers Explain

By David Hodes

June 24, 2019

Abstract / Synopsis: 


As more developments in the industry increase – from the passage of the 2018 Farm Bill legalizing hemp to hearings in Congress about fixing banking issues and enabling the government to provide small business loans – it’s time to take the pulse of the industry from some of the movers and shakers in the science community.


Here, two of the more prominent researchers in the cannabis industry – Dorothy “Dot” Colagiovanni, PhD, vice president of product development for Next Frontier BioSciences; and Cindy Orser, PhD, chief science officer for Digipath Labs – talk about how they see the industry today, what they expect going forward, and why they think the cannabis plant is finally beginning to emerge into the spotlight as one of the most intriguing, and beneficial, plants known to man.


Read the full article here: Taking the Pulse of the Industry Today: Two Prominent Researchers Explain

14 Jul 2019

High-Resolution Tandem MS Applications in Cannabis Product Development

By Kris Chupka

June 14, 2019

Abstract / Synopsis:


As cannabis legalization gains momentum, an emerging industry has been created that has a need for accurate, reliable and innovative analytical testing. In my role as Director of Analytical Chemistry at Next Frontier Biosciences, I chose high-resolution liquid chromatography/mass spectrometry (LC/MS) to meet these needs. In this article, I will discuss applications in routine testing (potency and contaminants) as well as those more specialized (terpenes, lipids, etc.).


Tandem quadrupole/time-of-flight (QTOF) mass spectrometry is shown to be a valuable tool in routine and custom applications that will contribute to the next generation of cannabis products. LC/MS capability in the cannabis laboratory goes well beyond contaminate testing currently used in most cannabis third-party testing labs. 


Read the full article here: High-Resolution Tandem MS Applications in Cannabis Product Development