27 Mar 2019

Is the Endocannabinoid System the Key to Happiness?

A new article from the Cannabis Business Executive website: Is the Endocannabinoid System the Key to Happiness?

 

Have you ever heard the saying, “happy wife, happy life?”  What makes that wife happy?  Is it the peacefulness of her family?  A stable job?  A loving partner?  Or, a healthy endocannabinoid system?  Could a well-functioning endocannabinoid system (ECS) be the key to our level of happiness?  We have heard stories about endocannabinoid deficiency syndrome, but what, if anything, is the proof that this relates to happiness?

 

We are fortunate to have a tool to evaluate the ECS’ role in happiness: a clinical study from the pharmaceutical industry’s interest in altering this system.  Pharma has been exploring the ECS’ role in appetite suppression and satiety since the first stoner ate Cheetos.  One of the first prescription drugs approved in Europe to modulate the ECS was Rimonabant/Zimulti (Acomplia).  This drug acts on the CB1 receptor as an antagonist—it blocks the activity of the targets such as anandamide; it was hypothesized that this would suppress appetite and be a useful weight reducing agent.  While the drug was approved in Europe for weight loss, the FDA did not approve this drug for use in the US.

 

The U.S. clinical studies, however, revealed how the CB1 receptor is involved with a healthy view of the world.  Studies demonstrated negative side effects of depression, anxiety and suicidal thoughts while patients were taking the drug.  These documented adverse effects provide direct evidence that blockade of the CB1 receptor, one of the main components of the ECS, leads to depressed, anxious and troubled individuals. U.S. regulators believed the risks outweighed the benefits of modest weight loss seen in the study and blocked its approval.

09 Mar 2019

MyMilligram – Verra Wellness: Micromist Tinctures

MyMilligram – Verra Wellness: Micromist Tinctures

Marcia Gagliardi at MyMilligram reviews Verra Wellness micromist tinctures – Verra Wellness: Micromist Tinctures

“Their line of Micromist Tinctures comes in three different ratios: 20:1, 1:1, or 1:10 (CBD:THC). They also come in two flavors: a refreshing peppermint or fruity-zippy strawberry-ginger, and it’s really hard to detect any cannabis in either. The peppermint is my preference—it tastes natural and gives you fresh breath while it does its magic. “

16 Jan 2019

New mechanisms of activity for CBD revealed

Clinical studies indicate that cannabidiol (CBD), the primary nonaddictive component of cannabis that interacts with the serotonin (5-HT)1A receptor, may possess analgesic and anxiolytic effects. However, its effects on 5-HT neuronal activity, as well as its impact on models of neuropathic pain are unknown.

Cannabis triggers a complex set of experiences in humans including euphoria, heightened sensitivity to external experience, and relaxation. The primary noneuphorizing and nonaddictive compound of cannabis, cannabidiol(CBD), has recently been shown to possess considerable therapeutic potential for treating a wide range of
disorders such as chronic pain, nausea, epilepsy, pychosis, and anxiety.

Read more Todays Practitioner web site

12 Sep 2018

Devising next-generation products and the unmet needs of non-traditional cannabis consumers

Devising next-generation products and the unmet needs of non-traditional cannabis consumers

VP of Product Development Dorothy “Dot” Colagiovanni

Devising next-generation products geared towards the unmet needs of non-traditional cannabis consumers.

“I like to think that we’re a part of  ‘Cannabis 2.0’ at this point,” says Colagiovanni.

 

Colagiovanni considers “Cannabis 1.0” to include smoked cannabis, baked goods, products sometimes manufactured haphazardly; whereas, Next Frontier Biosciences has developed a line of products, called Verra Wellness, which includes topicals, sublingual sprays, and — perhaps most uniquely — nasal sprays.

 

The company doesn’t make the products itself; that’s done by third-party manufacturer, RMZ Colorado, which is licensed in Colorado to make marijuana-infused goods. Colagiovanni describes Next Frontier Biosciences as “an IP holding company and brand management company.” At its Westminster lab, Colagiovanni is doing R&D work on formulating pills and effervescent tablets, which will eventually contain cannabis. (There’s no cannabis present for research use at Next Frontier’s lab.)

 

The company’s slogan is “Where Biotech Meets Cannabis.” Co-founder and Chief Scientific Officer Paul Johnson spent “40 years in biotech in nasal drug development, particularly, with over 100 patents to his name — so, a lot of experience in that area,” says Colagiovanni. She adds, “Our scientific team is [made up of] analytical chemists and chemical engineers.”

See more at the Company Week article.

29 May 2018

Cannabis Science

Cannabis Science

Cannabis Science

Depending upon your industry perspective, when I use the term “cannabis science” you may be thinking of optimal plant growth conditions, the latest extraction techniques, or manufacturing technology. Cannabis science is broadly used and has many applications.

 

From my perspective, cannabis science relates to the interactions that take place in the body following consumption of a cannabinoid-containing product. By definition, a cannabinoid is a substance that binds to a specific cannabinoid receptor and can be produced in one of three ways: it can be produced in the body, derived from plants, or chemically.

 

The focus of this article is on the “why and how” that enables cannabis to act in the body.

 

The Endocannabinoid System

Why cannabis is able to cause biological effects because of the endocannabinoid system (or ECS). Only identified in the last 20 years, The ECS is increasingly recognized as essential to maintaining homeostasis, or balance, in the body. Detected in diverse species ranging from mushrooms to rats to humans, the ECS plays critical roles for regulating mood, sleep, pain and inflammation.

 

The components of the ECS include the cannabinoid receptors CB1 and CB2, the endocannabinoids that bind to the receptors, including Anandamide, NADA and 2AG, and the enzymes that synthesize and degrade these compounds. It is a “lock and key” system that allows only certain keys to open the locks and initiate a cascade of effects.  Each endocannabinoid binds differently to the receptors to activate or inhibit their responses. The pieces of the ECS work together to synthesize the endocannabinoids “on demand” and transmit chemical messages between cells.

Why Does Cannabis Alter My Brain?

17 Apr 2018

Next Frontier Biosciences Expands Verra Wellness Product Lines into California via Partnership with BAS Research

DENVER, April 12, 2018 /PRNewswire/ — Next Frontier Biosciences, a Colorado-based cannabis drug development and commercialization firm, today announced a partnership with BAS Research to bring its Verra Wellness line of premium cannabis-infused products to the California medical and adult-use marijuana markets. The Verra Wellness line of sublingual sprays and topical salves are anticipated to be available in California by Q3 2018.

 

“Expanding into California allows Next Frontier Biosciences to tap into the state’s multibillion-dollar marijuana industry–gaining access to what is projected to be the world’s largest legal cannabis market,” said Marc Graboyes, Co-Founder and CEO of Next Frontier Biosciences. “Our cutting-edge Verra Wellness products are designed to meet the California market’s need for clean, consistent and trustworthy products that allow consumers the ability to manage their dose. Our partner, BAS Research, shares this vision for the industry’s future and we are excited to work together to pursue our mutual goal of providing consumers with best-in-class cannabis products that are safe, effective and discreet.”

 

Read more PRN Newswire site.

11 Apr 2018

It’s All in the Delivery

It’s All in the Delivery: Cannabis Consumption and Emerging Technologies

by Dr. Dorothy Colagiovanni, VP Product Development, Next Frontier Biosciences

The cannabis industry is rapidly evolving, with new brands and products launching every week. For both new and regular consumers alike, the sheer number of options when walking into a dispensary can be intimidating. As additional states legalize adult MJ use, it is crucial for consumers to learn about cannabis delivery technologies.  Scientists and manufacturers have created numerous ways to enjoy the cannabis plant.  Learning about the advantages and disadvantages of each offering can help to more easily navigate the dispensary to find the best choice for your unique needs and lifestyle. Below is a brief outline of the available cannabis delivery methods, meant to serve as a guide to better understanding how each one works with accompanying strengths and weaknesses.

Smokable Products

For decades marijuana use has been associated with smoking, and although this is no longer the only way to enjoy the benefits of the plant, it is still a very popular method. When the flower of the female cannabis plant is heated THCa is converted to THC, the psychoactive component of cannabis.  The effects are experienced quickly, whether using a pipe, bong or joint.  New devices can even convert water bottles instantly into single use bongs. Smoking methods can, however, lead to long-term lung problems, including bronchitis. The instant effects and relatively low-cost make smoking a tempting option compared to other delivery methods; however, consumers should bear in mind potential health impacts.

Read more at the Cannabis Business Executive site