26 Apr 2017

Development of Best-In-Class Medical Cannabis Products

Presented at ICR 2017 meeting, Pueblo, CO

At Next Frontier Biosciences, we use advanced pharmaceutical methods to develop best-in-class purified cannabinoid products for nasal and sublingual administration. Our development program is science-based and evidence-driven to achieve traditional pharmaceutical levels of quality or better. Our cannabis products are formulated using highly purified cannabinoids and GRAS excipients, and we use a high-resolution mass spectrometer with HPLC separation to evaluate product potency, stability, and chemical identity of degradants and contaminants.  Read more …   Formulation Poster 3 x 5 foot_PRESS

26 Apr 2017

Assessing Cannabinoid Permeability in a Mouse Dermal Administration Model

Presented at ICR 2017 meeting, Pueblo, CO

Cannabinoids are extremely lipophilic substances with LogPvalues >5.  This makes cannabinoids amenable to formulation only with hydrophobic preparations for topical administration. We sought to evaluate various oil based preparations of Δ9-tetrahydrocannabinol (THC).  The starting formulation (base) did not have permeation enhancers while other formulations did.  Preparations were analyzed by liquid chromatography (LC)-mass spectrometry (MS) to confirm potency and chemical identity prior to study initiation.  Read more…  Bioanalytical Poster 3 x 5 foot_PRESS